Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast

Fcp1 is a protein phosphatase that facilitates transcription elongation and termination by dephosphorylating the C-terminal domain of RNA polymerase II. High-throughput genetic screening and gene expression profiling of fcp1 mutants revealed a novel connection to Cdk8, the Mediator complex kinase su...

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Vydáno v:J Biol Chem
Hlavní autoři: Aristizabal, Maria J., Dever, Kristy, Negri, Gian Luca, Shen, Mary, Hawe, Nicole, Benschop, Joris J., Holstege, Frank C. P., Krogan, Nevan J., Sadowski, Ivan, Kobor, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827322/
https://ncbi.nlm.nih.gov/pubmed/31506296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008515
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