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RecQL4 tethering on the pre-replicative complex induces unscheduled origin activation and replication stress in human cells
Sequential activation of DNA replication origins is precisely programmed and critical to maintaining genome stability. RecQL4, a member of the conserved RecQ family of helicases, plays an essential role in the initiation of DNA replication in mammalian cells. Here, we showed that RecQL4 protein teth...
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| Yayımlandı: | J Biol Chem |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6827294/ https://ncbi.nlm.nih.gov/pubmed/31519754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009996 |
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