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A robust and economical pulse-chase protocol to measure the turnover of HaloTag fusion proteins

The self-labeling protein HaloTag has been used extensively to determine the localization and turnover of proteins of interest at the single-cell level. To this end, halogen-substituted alkanes attached to diverse fluorophores are commercially available that allow specific, irreversible labeling of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Merrill, Ronald A., Song, Jianing, Kephart, Rikki A., Klomp, Annette J., Noack, Claire E., Strack, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827285/
https://ncbi.nlm.nih.gov/pubmed/31511325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010596
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