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Unraveling the Heterogeneous Mutational Signature of Spontaneously Developing Tumors in MLH1(−/−) Mice
Mismatch repair deficient (MMR-D) tumors exemplify the prototypic hypermutator phenotype. Owing to the high mutation rates, plenty of neo-antigens are present on the tumor cells’ surface, ideally shared among different cancer types. The MLH1 knock out mouse represents a preclinical model that resemb...
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| Pubblicato in: | Cancers (Basel) |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6827043/ https://ncbi.nlm.nih.gov/pubmed/31581674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101485 |
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