In vivo vaccination with cell line-derived whole tumor lysates: neoantigen quality, not quantity matters

BACKGROUND: Cancer vaccines provide a complex source of neoantigens. Still, increasing evidence reveals that the neoantigen quality rather than the quantity is predictive for treatment outcome. METHODS: Using the preclinical Mlh1(−/−) tumor model, we performed a side-by side comparison of two autolo...

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Gepubliceerd in:J Transl Med
Hoofdauteurs: Salewski, Inken, Gladbach, Yvonne Saara, Kuntoff, Steffen, Irmscher, Nina, Hahn, Olga, Junghanss, Christian, Maletzki, Claudia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7579816/
https://ncbi.nlm.nih.gov/pubmed/33087163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02570-y
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