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Low-level inhibition of Hsp90 forces cells to tip their (antigenic) hand

Low-level inhibition of hsp90 enhances the antigenicity of cells whereas high-level inhibition diminishes antigenicity. The mechanism(s) by which hsp90 determines antigenicity are only partially clear. Regardless, these observations have profound implications in protein trafficking and antigen prese...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Srivastava, Pramod K., Callahan, Margaret K.
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825573/
https://ncbi.nlm.nih.gov/pubmed/31444251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2094
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