Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia

PURPOSE: Uniparental disomy UPD is a way cancer cells duplicate a mutated gene causing loss of heterozygosity (LOH). Patients with cytogenetically normal acute myeloid leukemia (CN-AML) do not have microscopically detectable chromosome abnormalities, but can harbor UPDs. We examined the prognostic s...

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Publié dans:Clin Cancer Res
Auteurs principaux: Walker, Christopher J., Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Mrózek, Krzysztof, Liyanarachchi, Sandya, Song, Chi, Nicolet, Deedra, Blachly, James S., Bill, Marius, Papaioannou, Dimitrios, Oakes, Christopher C., Giacopelli, Brain, Genutis, Luke K., Maharry, Sophia E., Orwick, Shelley, Archer, Kellie J., Powell, Bayard L., Kolitz, Jonathan E., Uy, Geoffrey L., Wang, Eunice S., Carroll, Andrew J., Stone, Richard M., Byrd, John C., de la Chapelle, Albert, Bloomfield, Clara D.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825549/
https://ncbi.nlm.nih.gov/pubmed/31375516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0725
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