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Time-trend impact on treatment estimation in two-arm clinical trials with a binary outcome and Bayesian response adaptive randomization
Clinical trial design and analysis often assume study population homogeneity, although patient baseline profile and standard of care may evolve over time, especially in trials with long recruitment periods. The time-trend phenomenon can affect the treatment estimation and the operating characteristi...
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| Publicado no: | J Biopharm Stat |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825522/ https://ncbi.nlm.nih.gov/pubmed/31017843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2019.1607368 |
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