Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy

Cancer development is driven by activated oncogenes and loss of tumor suppressors. While oncogene inhibitors have entered routine clinical practice, tumor suppressor reactivation therapy remains to be established. For the most frequently inactivated tumor suppressor p53, genetic mouse models have de...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Klimovich, Boris, Mutlu, Samet, Schneikert, Jean, Elmshäuser, Sabrina, Klimovich, Maria, Nist, Andrea, Mernberger, Marco, Timofeev, Oleg, Stiewe, Thorsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825290/
https://ncbi.nlm.nih.gov/pubmed/31611375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910255116
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