Targeting centrosome amplification, an Achilles' heel of cancer

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes and indeed can cause cancer in flies and mammals. However, cells have to actively manage CA, often by cen...

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Dades bibliogràfiques
Publicat a:Biochem Soc Trans
Autors principals: Sabat-Pośpiech, Dorota, Fabian-Kolpanowicz, Kim, Prior, Ian A., Coulson, Judy M., Fielding, Andrew B.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2019
Matèries:
Review Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824836/
https://ncbi.nlm.nih.gov/pubmed/31506331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190034
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