Targeting centrosome amplification, an Achilles' heel of cancer

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes and indeed can cause cancer in flies and mammals. However, cells have to actively manage CA, often by cen...

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Библиографические подробности
Опубликовано в: :Biochem Soc Trans
Главные авторы: Sabat-Pośpiech, Dorota, Fabian-Kolpanowicz, Kim, Prior, Ian A., Coulson, Judy M., Fielding, Andrew B.
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2019
Предметы:
Review Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824836/
https://ncbi.nlm.nih.gov/pubmed/31506331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190034
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