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Targeting centrosome amplification, an Achilles' heel of cancer

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes and indeed can cause cancer in flies and mammals. However, cells have to actively manage CA, often by cen...

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Podrobná bibliografie
Vydáno v:Biochem Soc Trans
Hlavní autoři: Sabat-Pośpiech, Dorota, Fabian-Kolpanowicz, Kim, Prior, Ian A., Coulson, Judy M., Fielding, Andrew B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824836/
https://ncbi.nlm.nih.gov/pubmed/31506331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190034
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