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Targeting centrosome amplification, an Achilles' heel of cancer
Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes and indeed can cause cancer in flies and mammals. However, cells have to actively manage CA, often by cen...
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| Udgivet i: | Biochem Soc Trans |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6824836/ https://ncbi.nlm.nih.gov/pubmed/31506331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190034 |
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