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Targeting centrosome amplification, an Achilles' heel of cancer

Due to cell-cycle dysregulation, many cancer cells contain more than the normal compliment of centrosomes, a state referred to as centrosome amplification (CA). CA can drive oncogenic phenotypes and indeed can cause cancer in flies and mammals. However, cells have to actively manage CA, often by cen...

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Foilsithe in:Biochem Soc Trans
Main Authors: Sabat-Pośpiech, Dorota, Fabian-Kolpanowicz, Kim, Prior, Ian A., Coulson, Judy M., Fielding, Andrew B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Portland Press Ltd. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824836/
https://ncbi.nlm.nih.gov/pubmed/31506331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20190034
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