Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish

β-glucosidases [GBA1 (glucocerebrosidase) and GBA2] are ubiquitous essential enzymes. Lysosomal GBA1 and cytosol-facing GBA2 degrade glucosylceramide (GlcCer); GBA1 deficiency causes Gaucher disease, a lysosomal storage disorder characterized by lysosomal accumulation of GlcCer, which is partly conv...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Lipid Res
Päätekijät: Lelieveld, Lindsey T., Mirzaian, Mina, Kuo, Chi-Lin, Artola, Marta, Ferraz, Maria J., Peter, Remco E. A., Akiyama, Hisako, Greimel, Peter, van den Berg, Richard J. B. H. N., Overkleeft, Herman S., Boot, Rolf G., Meijer, Annemarie H., Aerts, Johannes M. F. G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824494/
https://ncbi.nlm.nih.gov/pubmed/31562193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000154
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