Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression

Tissue engineering may address organ shortages currently limiting clinical transplantation. Off-the-shelf engineered vascularized organs will likely use allogeneic endothelial cells (ECs) to construct microvessels required for graft perfusion. Vasculogenic ECs can be differentiated from committed pr...

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Udgivet i:JCI Insight
Main Authors: Merola, Jonathan, Reschke, Melanie, Pierce, Richard W., Qin, Lingfeng, Spindler, Susann, Baltazar, Tania, Manes, Thomas D., Lopez-Giraldez, Francesc, Li, Guangxin, Bracaglia, Laura G., Xie, Catherine, Kirkiles-Smith, Nancy, Saltzman, W. Mark, Tietjen, Gregory T., Tellides, George, Pober, Jordan S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824302/
https://ncbi.nlm.nih.gov/pubmed/31527312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129739
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