Blocking MHC class II on human endothelium mitigates acute rejection

Acute allograft rejection is mediated by host CD8(+) cytotoxic T lymphocytes (CTL) targeting graft class I major histocompatibility complex (MHC) molecules. In experimental rodent models, rejection requires differentiation of naive CD8(+) T cells into alloreactive CTL within secondary lymphoid organ...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Abrahimi, Parwiz, Qin, Lingfeng, Chang, William G., Bothwell, Alfred L.M., Tellides, George, Saltzman, W. Mark, Pober, Jordan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756651/
https://ncbi.nlm.nih.gov/pubmed/26900601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85293
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