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Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response

Alterations in DNA damage response (DDR) is one of the several hallmarks of cancer. Genomic instability resulting from a disrupted DDR mechanism is known to contribute to cancer progression, and are subjected to radiation, cytotoxic, or more recently targeted therapies with limited success. Syntheti...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Das, Shaoli, Camphausen, Kevin, Shankavaram, Uma
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823874/
https://ncbi.nlm.nih.gov/pubmed/31709193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01136
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