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Generalization of the time-to-event continual reassessment method to bivariate outcomes

This article considers the problem of designing Phase I-II clinical trials with delayed toxicity and efficacy outcomes. The proposed design is motivated by a Phase I-II study evaluating all-trans retinoic acid (ATRA) in combination with a fixed dose of daratumumab in the treatment of relapsed or ref...

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Dades bibliogràfiques
Publicat a:J Biopharm Stat
Autors principals: Yan, Donglin, Tait, Christopher, Wages, Nolan A., Kindwall-Keller, Tamila, Dressler, Emily V.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823630/
https://ncbi.nlm.nih.gov/pubmed/31264936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2019.1634087
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