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Generalization of the time-to-event continual reassessment method to bivariate outcomes
This article considers the problem of designing Phase I-II clinical trials with delayed toxicity and efficacy outcomes. The proposed design is motivated by a Phase I-II study evaluating all-trans retinoic acid (ATRA) in combination with a fixed dose of daratumumab in the treatment of relapsed or ref...
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| Gepubliceerd in: | J Biopharm Stat |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6823630/ https://ncbi.nlm.nih.gov/pubmed/31264936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2019.1634087 |
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