The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro

Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. The tumour suppressor TP53 is a critical gene in carcinogenesis and frequently mutated in AA-induced urothelial tumours. We investigated the impact of p53 on AAI-induced nephrotoxicity and DNA damage in vi...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Sborchia, Mateja, De Prez, Eric G., Antoine, Marie-Hélène, Bienfait, Lucie, Indra, Radek, Valbuena, Gabriel, Phillips, David H., Nortier, Joëlle L., Stiborová, Marie, Keun, Hector C., Arlt, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Genotoxicity and Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6823306/
https://ncbi.nlm.nih.gov/pubmed/31602497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-019-02578-4
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