Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro. We evaluated th...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Arlt, Volker M., Meinl, Walter, Florian, Simone, Nagy, Eszter, Barta, Frantisek, Thomann, Marlies, Mrizova, Iveta, Krais, Annette M., Liu, Maggie, Richards, Meirion, Mirza, Amin, Kopka, Klaus, Phillips, David H., Glatt, Hansruedi, Stiborova, Marie, Schmeiser, Heinz H.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Genotoxicity and Carcinogenicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364269/
https://ncbi.nlm.nih.gov/pubmed/27557898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1808-6
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