Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro. We evaluated th...

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Bibliografiske detaljer
Udgivet i:Arch Toxicol
Main Authors: Arlt, Volker M., Meinl, Walter, Florian, Simone, Nagy, Eszter, Barta, Frantisek, Thomann, Marlies, Mrizova, Iveta, Krais, Annette M., Liu, Maggie, Richards, Meirion, Mirza, Amin, Kopka, Klaus, Phillips, David H., Glatt, Hansruedi, Stiborova, Marie, Schmeiser, Heinz H.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
Fag:
Genotoxicity and Carcinogenicity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364269/
https://ncbi.nlm.nih.gov/pubmed/27557898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1808-6
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