Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro. We evaluated th...

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Bibliografische gegevens
Gepubliceerd in:Arch Toxicol
Hoofdauteurs: Arlt, Volker M., Meinl, Walter, Florian, Simone, Nagy, Eszter, Barta, Frantisek, Thomann, Marlies, Mrizova, Iveta, Krais, Annette M., Liu, Maggie, Richards, Meirion, Mirza, Amin, Kopka, Klaus, Phillips, David H., Glatt, Hansruedi, Stiborova, Marie, Schmeiser, Heinz H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Berlin Heidelberg 2016
Onderwerpen:
Genotoxicity and Carcinogenicity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5364269/
https://ncbi.nlm.nih.gov/pubmed/27557898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-016-1808-6
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