Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo

Aristolochic acid I (AAI) is a natural plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. One of the most efficient enzymes reductively activating AAI to species forming AAI-DNA adducts is cytosolic NAD(P)H:quinone oxidoredu...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: Dračínská, Helena, Bárta, František, Levová, Kateřina, Hudecová, Alena, Moserová, Michaela, Schmeiser, Heinz H., Kopka, Klaus, Frei, Eva, Arlt, Volker M., Stiborová, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804751/
https://ncbi.nlm.nih.gov/pubmed/26845733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.01.011
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