Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. Individual susceptibility to AA-induced disease likely reflects individual differences in enzymes that metabolize AA. Herein, we evaluated AAI metabolism by human cytochrome P450 (CYP) 1A1 and 1A2 in two C...

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Detalhes bibliográficos
Main Authors: Stiborová, Marie, Levová, Kateřina, Bárta, František, Shi, Zhanquan, Frei, Eva, Schmeiser, Heinz H., Nebert, Daniel W., Phillips, David H., Arlt, Volker M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Biotransformation and Toxicokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262855/
https://ncbi.nlm.nih.gov/pubmed/22086975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr306
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