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Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30(−) Tumors

Chimeric antigen receptor (CAR)-engineered T cells are efficacious in controlling advanced leukemia and lymphoma, however, they fail in the treatment of solid cancer, which is thought to be due to insufficient T cell activation. We revealed that the immune response of CAR T cells with specificity fo...

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Pubblicato in:Mol Ther
Autori principali: Hombach, Andreas A., Rappl, Gunter, Abken, Hinrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822283/
https://ncbi.nlm.nih.gov/pubmed/31331813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.06.007
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