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Most Do, but Some Do Not: CD4(+)CD25(−) T Cells, but Not CD4(+)CD25(+) Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR)

Evidences are accumulating that CD4(+) T cells can physiologically mediate antigen specific target cell lysis. By circumventing major histocompatibility complex (MHC)-restrictions through an engineered chimeric antigen receptor (CAR), CD4(+) T cells lyse defined target cells as efficiently as do CD8...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Hombach, Andreas A., Abken, Hinrich
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615327/
https://ncbi.nlm.nih.gov/pubmed/28850063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9090112
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