Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells

Adoptive T-cell therapy has recently shown promise in initiating a lasting anti-tumor response with spectacular therapeutic success in some cases. Specific T-cell therapy, however, is limited since a number of cancer cells are not recognized by T cells due to various mechanisms including the limited...

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Bibliographic Details
Main Authors: Chmielewski, Markus, Hombach, Andreas A., Abken, Hinrich
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822734/
https://ncbi.nlm.nih.gov/pubmed/24273543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00371
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