Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity

Treatment of cancer patients by adoptive T cell therapy has yielded promising results. In solid tumors, however, T cells encounter a hostile environment, in particular with increased inflammatory activity as a hallmark of the tumor milieu that goes along with abundant reactive oxygen species (ROS) t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Immunol
Egile Nagusiak: Ligtenberg, Maarten A., Mougiakakos, Dimitrios, Mukhopadhyay, Madhura, Witt, Kristina, Lladser, Alvaro, Chmielewski, Markus, Riet, Tobias, Abken, Hinrich, Kiessling, Rolf
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: AAI 2016
Gaiak:
Immunotherapy and Vaccines
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705591/
https://ncbi.nlm.nih.gov/pubmed/26673145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401710
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