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Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation”

Cytokine-induced killer (CIK) cells raised interest for use in cellular antitumor therapy due to their capability to recognize and destroy autologous tumor cells in a HLA-independent fashion. The antitumor attack of CIK cells, predominantly consisting of terminally differentiated CD8(+)CD56(+) cells...

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Detalhes bibliográficos
Main Authors: Hombach, Andreas A, Rappl, Gunter, Abken, Hinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863798/
https://ncbi.nlm.nih.gov/pubmed/23985696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.192
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