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Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody

Single-domain antibodies (VHHs or nanobodies), developed from heavy chain-only antibodies of camelids, are gaining attention as next-generation therapeutic agents. Despite their small size, the high affinity and specificity displayed by VHHs for antigen molecules rival those of IgGs. How such small...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Akiba, Hiroki, Tamura, Hiroko, Kiyoshi, Masato, Yanaka, Saeko, Sugase, Kenji, Caaveiro, Jose M. M., Tsumoto, Kouhei
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820745/
https://ncbi.nlm.nih.gov/pubmed/31664051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50722-y
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