Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T(FH) cells.

Sustained TCR stimulation is required for maintaining germinal center T follicular helper cells (GC-T(FH)). Paradoxically, TCR activation induces interleukin-2 receptor (IL-2R) expression and IL-2 production, thereby initiating a feedback loop of IL-2 signaling that normally inhibits T(FH) cells. It...

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Publicat a:Sci Immunol
Autors principals: Papillion, Amber, Powell, Michael D., Chisolm, Danielle A., Bachus, Holly, Fuller, Michael J., Weinmann, Amy S., Villarino, Alejandro, O’Shea, John J., León, Beatriz, Oestreich, Kenneth J., Ballesteros-Tato, André
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820141/
https://ncbi.nlm.nih.gov/pubmed/31519812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw7636
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