Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties

Poly(ethylene glycol) (PEG), a linear polymer known for its “stealth” properties, is commonly used to passivate the surface of biomedical implants and devices, and is conjugated to biologic drugs to improve their pharmacokinetics. However, its antigenicity is a growing concern. Here, we investigated...

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Gepubliceerd in:Adv Healthc Mater
Hoofdauteurs: Joh, Daniel Y., Zimmers, Zackary, Avlani, Manav, Heggestad, Jacob T., Aydin, Hakan B., Ganson, Nancy, Kumar, Shourya, Fontes, Cassio, Achar, Rohan K., Hershfield, Michael S., Hucknall, Angus M., Chilkoti, Ashutosh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819148/
https://ncbi.nlm.nih.gov/pubmed/30908902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201801177
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