Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties

Poly(ethylene glycol) (PEG), a linear polymer known for its “stealth” properties, is commonly used to passivate the surface of biomedical implants and devices, and is conjugated to biologic drugs to improve their pharmacokinetics. However, its antigenicity is a growing concern. Here, we investigated...

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Bibliografske podrobnosti
izdano v:Adv Healthc Mater
Main Authors: Joh, Daniel Y., Zimmers, Zackary, Avlani, Manav, Heggestad, Jacob T., Aydin, Hakan B., Ganson, Nancy, Kumar, Shourya, Fontes, Cassio, Achar, Rohan K., Hershfield, Michael S., Hucknall, Angus M., Chilkoti, Ashutosh
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819148/
https://ncbi.nlm.nih.gov/pubmed/30908902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201801177
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