Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties

Poly(ethylene glycol) (PEG), a linear polymer known for its “stealth” properties, is commonly used to passivate the surface of biomedical implants and devices, and is conjugated to biologic drugs to improve their pharmacokinetics. However, its antigenicity is a growing concern. Here, we investigated...

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Publicado en:Adv Healthc Mater
Main Authors: Joh, Daniel Y., Zimmers, Zackary, Avlani, Manav, Heggestad, Jacob T., Aydin, Hakan B., Ganson, Nancy, Kumar, Shourya, Fontes, Cassio, Achar, Rohan K., Hershfield, Michael S., Hucknall, Angus M., Chilkoti, Ashutosh
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819148/
https://ncbi.nlm.nih.gov/pubmed/30908902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201801177
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