AAV8-vectored suprachoroidal gene transfer produces widespread ocular transgene expression

There has been great progress in ocular gene therapy, but delivery of viral vectors to the retinal pigmented epithelium (RPE) and retina can be challenging. Subretinal injection, the preferred route of delivery for most applications, requires a surgical procedure that has risks. Herein we report a n...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Ding, Kun, Shen, Jikui, Hafiz, Zibran, Hackett, Sean F., Silva, Raquel Lima e, Khan, Mahmood, Lorenc, Valeria E., Chen, Daiqin, Chadha, Rishi, Zhang, Minie, Van Everen, Sherri, Buss, Nicholas, Fiscella, Michele, Danos, Olivier, Campochiaro, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6819121/
https://ncbi.nlm.nih.gov/pubmed/31408444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129085
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