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Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

T cell acute lymphoblastic leukemia (T-ALL) is a serious hematologic malignancy that occurs in children and young adults. Current therapies include intensive chemotherapy and ionizing radiation that preferentially kill malignant cells. Unfortunately, they are frequently accompanied by unintended neg...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Ying, Gundelach, Justin, Lindquist, Lonnie D., Baker, Darren J., van Deursen, Jan, Bram, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6818774/
https://ncbi.nlm.nih.gov/pubmed/31661505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224172
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