Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

Neutrophils respond to various stimuli by decondensing and releasing nuclear chromatin characterized by citrullinated histones as neutrophil extracellular traps (NETs). This achieves pathogen immobilization or initiation of thrombosis, yet the molecular mechanisms of NET formation remain elusive. Pe...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Gößwein, Stefanie, Lindemann, Aylin, Mahajan, Aparna, Maueröder, Christian, Martini, Eva, Patankar, Jay, Schett, Georg, Becker, Christoph, Wirtz, Stefan, Naumann-Bartsch, Nora, Bianchi, Marco E., Greer, Peter A., Lochnit, Günter, Herrmann, Martin, Neurath, Markus F., Leppkes, Moritz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817590/
https://ncbi.nlm.nih.gov/pubmed/31695698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02481
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