High sensitivity LC-MS profiling of antibody-drug conjugates with difluoroacetic acid ion pairing

Reversed-phase liquid chromatography (RPLC) separations of proteins using optical detection generally use trifluoroacetic acid (TFA) because it is a strong, hydrophobic acid and a very effective ion-pairing agent for minimizing chromatographic secondary interactions. Conversely and in order to avoid...

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Publicado en:MAbs
Autores principales: Nguyen, Jennifer M., Smith, Jacquelynn, Rzewuski, Susan, Legido-Quigley, Cristina, Lauber, Matthew A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816370/
https://ncbi.nlm.nih.gov/pubmed/31500514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1658492
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