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High sensitivity LC-MS profiling of antibody-drug conjugates with difluoroacetic acid ion pairing
Reversed-phase liquid chromatography (RPLC) separations of proteins using optical detection generally use trifluoroacetic acid (TFA) because it is a strong, hydrophobic acid and a very effective ion-pairing agent for minimizing chromatographic secondary interactions. Conversely and in order to avoid...
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| Vydáno v: | MAbs |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6816370/ https://ncbi.nlm.nih.gov/pubmed/31500514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1658492 |
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