MicroRNA-455-3p mediates GATA3 tumor suppression in mammary epithelial cells by inhibiting TGF-β signaling

GATA3 is a basic and essential transcription factor that regulates many pathophysiological processes and is required for the development of mammary luminal epithelial cells. Loss-of-function GATA3 alterations in breast cancer are associated with poor prognosis. Here, we sought to understand the tumo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Zeng, Yi, Gao, Tianyang, Huang, Wei, Yang, Yang, Qiu, Rongfang, Hou, Yongqiang, Yu, Wenqian, Leng, Shuai, Feng, Dandan, Liu, Wei, Teng, Xu, Yu, Hefen, Wang, Yan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Gene Regulation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816095/
https://ncbi.nlm.nih.gov/pubmed/31492753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010800
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