Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

Matrine, an alkaloid isolated from Sophora flavescens, possesses a wide range of pharmacological properties. However, the use of matrine in clinical practice is limited due to its toxic effects. The present study investigated the roles of mitochondria and reactive oxygen species (ROS) in matrine-ind...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: You, Longtai, Yang, Chunjing, Du, Yuanyuan, Liu, Yi, Chen, Gongsen, Sai, Na, Dong, Xiaoxv, Yin, Xingbin, Ni, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815593/
https://ncbi.nlm.nih.gov/pubmed/31737162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1045345
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