Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

Matrine, an alkaloid isolated from Sophora flavescens, possesses a wide range of pharmacological properties. However, the use of matrine in clinical practice is limited due to its toxic effects. The present study investigated the roles of mitochondria and reactive oxygen species (ROS) in matrine-ind...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: You, Longtai, Yang, Chunjing, Du, Yuanyuan, Liu, Yi, Chen, Gongsen, Sai, Na, Dong, Xiaoxv, Yin, Xingbin, Ni, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815593/
https://ncbi.nlm.nih.gov/pubmed/31737162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1045345
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