Discovery of Dual-acting Opioid Ligand and TRPV1 Antagonists as Novel Therapeutic Agents for Pain

In order to discover a novel type of analgesic, we investigated dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single targeting. Based on a combination approach, a series of...

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Publicado no:Eur J Med Chem
Main Authors: Lee, Hobin, Ahn, Songyeon, Ann, Jihyae, Ha, Heejin, Yoo, Young Dong, Kim, Young Ho, Hwang, Ji-Young, Hur, Kwang-Hyun, Jang, Choon-Gon, Pearce, Larry V., Esch, Timothy E., Lewin, Nancy E., Blumberg, Peter M., Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815263/
https://ncbi.nlm.nih.gov/pubmed/31472474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.111634
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