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Design of Fluorinated Cyclopropane Derivatives of 2-Phenylcyclopropylmethylamine Leading to Identification of a Selective Serotonin 2C (5-HT(2C)) Receptor Agonist without 5-HT(2B) Agonism
A new series of fluorinated 5-HT(2C) agonists were designed and synthesized on the basis of our previous work on 2-phenylcyclopropylmethylamines as a potential approach for the treatment of central nervous system disorders. Key fluorinated cyclopropane moieties were constructed through transition me...
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| Izdano u: | Eur J Med Chem |
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| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6815260/ https://ncbi.nlm.nih.gov/pubmed/31445232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.111626 |
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