Fungal Indole Alkaloid Biogenesis Through Evolution of a Bifunctional Reductase/Diels-Alderase

Prenylated indole alkaloids, such as the calmodulin inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approache...

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Publicat a:Nat Chem
Autors principals: Dan, Qingyun, Newmister, Sean A., Klas, Kimberly R., Fraley, Amy E., McAfoos, Timothy J., Somoza, Amber D., Sunderhaus, James D., Ye, Ying, Shende, Vikram V., Yu, Fengan, Sanders, Jacob N., Brown, W. Clay, Zhao, Le, Paton, Robert S., Houk, K. N., Smith, Janet L., Sherman, David H., Williams, Robert M.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815239/
https://ncbi.nlm.nih.gov/pubmed/31548667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0326-6
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