Fungal Indole Alkaloid Biogenesis Through Evolution of a Bifunctional Reductase/Diels-Alderase

Prenylated indole alkaloids, such as the calmodulin inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approache...

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Bibliografski detalji
Izdano u:Nat Chem
Glavni autori: Dan, Qingyun, Newmister, Sean A., Klas, Kimberly R., Fraley, Amy E., McAfoos, Timothy J., Somoza, Amber D., Sunderhaus, James D., Ye, Ying, Shende, Vikram V., Yu, Fengan, Sanders, Jacob N., Brown, W. Clay, Zhao, Le, Paton, Robert S., Houk, K. N., Smith, Janet L., Sherman, David H., Williams, Robert M.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815239/
https://ncbi.nlm.nih.gov/pubmed/31548667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0326-6
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