Fungal Indole Alkaloid Biogenesis Through Evolution of a Bifunctional Reductase/Diels-Alderase

Prenylated indole alkaloids, such as the calmodulin inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approache...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Chem
Egile Nagusiak: Dan, Qingyun, Newmister, Sean A., Klas, Kimberly R., Fraley, Amy E., McAfoos, Timothy J., Somoza, Amber D., Sunderhaus, James D., Ye, Ying, Shende, Vikram V., Yu, Fengan, Sanders, Jacob N., Brown, W. Clay, Zhao, Le, Paton, Robert S., Houk, K. N., Smith, Janet L., Sherman, David H., Williams, Robert M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815239/
https://ncbi.nlm.nih.gov/pubmed/31548667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0326-6
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