Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14

Endoplasmic reticulum (ER) stress plays an important role in metabolic diseases like obesity and type 2 diabetes mellitus (T2DM), although the underlying mechanisms and regulatory pathways remain to be elucidated. Here, we induced chronic low-grade ER stress in lean mice to levels similar to those i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Liu, Bin, Zhang, Zhijian, Hu, Yanyun, Lu, Yan, Li, Duanzhuo, Liu, Jie, Liao, Shengjie, Hu, Min, Wang, Yuxing, Zhang, Die, Chen, Yulu, Qian, Qilan, Lv, Xianfeng, Wu, Duojiao, Tan, Minjia, Hu, Cheng, Xiong, Xuelian, Li, Xiaoying
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815134/
https://ncbi.nlm.nih.gov/pubmed/31594848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907288116
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