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Differential misfolding properties of glaucoma-associated olfactomedin domains from human and mouse
Mutations in myocilin, predominantly within its olfactomedin (OLF) domain, are causative for the heritable form of open angle glaucoma in humans. Surprisingly, mice expressing Tyr423His mutant myocilin, corresponding to a severe glaucoma-causing mutation (Tyr437His) in human subjects, exhibit a weak...
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| Vydáno v: | Biochemistry |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6815101/ https://ncbi.nlm.nih.gov/pubmed/30802039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01309 |
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