Synthetic HDL Nanoconjugate Targets Neuroblastoma Stem Cells, Blocking Migration and Self-Renewal

BACKGROUND: Pathways critical for neuroblastoma (NB) cancer stem cell (CSC) function are targeted by 4,19,27-triacetyl withalongolide A (WGA-TA). Since NB cells and their CSCs highly overexpress the SR-B1 receptor that binds to sHDL, we hypothesized that a novel mimetic sHDL nanoparticle will be an...

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Detalhes bibliográficos
Publicado no:Surgery
Main Authors: Subramanian, C, White, PT, Kuai, R, Avinaash, K, Castle, VP, Moon, JJ, Timmermann, BM, Schwendeman, A, Cohen, MS
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814450/
https://ncbi.nlm.nih.gov/pubmed/29753460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2018.01.023
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