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The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

BACKGROUND: Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases. Grb2-a...

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Bibliografske podrobnosti
izdano v:	Cell Commun Signal
Main Authors:	Bongartz, Hannes, Gille, Karen, Hessenkemper, Wiebke, Mandel, Katharina, Lewitzky, Marc, Feller, Stephan M., Schaper, Fred
Format:	Artigo
Jezik:	Inglês
Izdano:	BioMed Central 2019
Teme:	Research
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6814103/ https://ncbi.nlm.nih.gov/pubmed/31651330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0451-2
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The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

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