The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

BACKGROUND: Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases. Grb2-a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Commun Signal
Auteurs principaux: Bongartz, Hannes, Gille, Karen, Hessenkemper, Wiebke, Mandel, Katharina, Lewitzky, Marc, Feller, Stephan M., Schaper, Fred
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6814103/
https://ncbi.nlm.nih.gov/pubmed/31651330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0451-2
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